Hypoxia is an almost universal hallmark of solid tumors Adaptation to hypoxia is critical for tumor survival and growth and is mediated largely by transcriptional activation of genes that facilitate short e g glucose transport

Wnt signaling via Beta catenin plays a central role in development and homeostasis This pathway is invariably disrupted in colorectal tumors and commonly affected by mutation in other cancers Wnt ligand binding and activating the

The CellSensor p53RE bla HCT 116 cell line contains a beta lactamase reporter gene under control of the p53 response element stably integrated into HCT 116 cells To construct this cell line the p53RE bla

The CellSensor Myc bla HCT116 cell line contains a beta lactamase reporter gene under the control of Myc binding sequences The construct was transduced into HCT116 cells using a lentiviral system HCT116 is a colon